Tumor necrosis factor receptor-mediated signaling pathways.
نویسندگان
چکیده
منابع مشابه
Tumor necrosis factor receptor-mediated signaling pathways
T UMOR necrosis factor c~ (TNF) ~ and tumor necrosis factor ~ (lymphotoxin) are two cytokines produced primarily by macrophages and lymphocytes, respectively. These cytokines are recognized by the same cell surface receptors and are associated with similar biological activities. Some of the well-known TNF effects include septic shock, cytotoxicity, inflammation, and cachexia. The role of TNF in...
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OBJECTIVE The proinflammtory cytokine tumor necrosis factor (TNF), primarily via TNF receptor 1 (TNFR1), induces nuclear factor-κB (NF-κB)-dependent cell survival, and c-Jun N-terminal kinase (JNK) and caspase-dependent cell death, regulating vascular endothelial cell (EC) activation and apoptosis. However, signaling by the second receptor, TNFR2, is poorly understood. The goal of this study wa...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1994
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.126.1.5